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Maelfait Jonathan
Research Teamleader
09/331.37.10
ORCID: 0000-0002-1476-0583
Areas of Expertise
- Nucleic acid sensors
- Z-DNA/Z-RNA binding proteins (ADAR1, ZBP1)
- Regulated cell death (apoptosis, necroptosis)
- Type I IFN signalling
Technology Transfer Potential
- Mouse models of autoinflammatory disease
- Antiviral therapies
Selected publications
- de Reuver, R. et al. ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. Nature 607, 784-789 (2022). Visit ➚
- Verdonck, S., Nemegeer, J., Vandenabeele, P. & Maelfait, J. Viral manipulation of host cell necroptosis and pyroptosis. Trends Microbiol 30, 593-605 (2022). Visit ➚
- de Reuver, R. et al. ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation. Cell Rep 36, 109500 (2021). Visit ➚
- Devos, M. et al. Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation. J Exp Med 217, e20191913 (2020). Visit ➚
- Maelfait, J. et al. Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis. EMBO J 36, 2529-2543 (2017) Visit ➚
Bibliography
Visit full bibliography ➚
Awards and or funding
